 |
Homepage 
Wat is nucleaire geneeskunde?
Wat is nucleaire geneeskunde? | Isotopic labelling of dendritic cells |
|
|
How antigenic signals are transfered to lymph nodes in order to initiate the immune reaction, is a crucial question in immunotherapy, particularly when it involves exogenous dendritic cells as antigen-presenting cells. Here the authors used isotopic labeling of exogenous dendritic cells to address this question...
Abstract Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules and that a proportion of injected DCs acquired host MHC molecules. These observations suggest that a bidirectional MHC molecule exchange occurs between migratory and resident DCs, a mechanism that may amplify antigen presentation in vivo.
|